Month: January 2021

Adding a certain compound to certain chemical reactions, such as: 50594-82-6, name is 3,4,5-Trichlorobenzotrifluoride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50594-82-6, Recommanded Product: 3,4,5-Trichlorobenzotrifluoride

(d) 1,3-Bis(2,6-dichloro-alpha,alpha,alpha-trifluoro-p-tolyloxy)benzene A mixture of 3,4,5-trichloro-alpha,alpha,alpha-trifluorotoluene (10 g. 0.04 mol), and the dipotassium salt of 1,3-dihydroxybenzene (4 g. 0.021 mol) in 150 ml. sulfolane is stirred and heated 70 minutes at ~120 C. The cooled reaction mixture is diluted with benzene (350 ml.) and washed once with water (1 l). Hexane (200 ml.) is added, and the solution washed with water (3*500 ml.) dried, filtered through activated silica gel (~25 g.), and the solvents removed. The residual oil is crystallized from a mixture of pentane and benzene to give 1,3-bis(2,6-dichloro-alpha,alpha,alpha-trifluoro-p-tolyloxy)benzene (5.3 g. 49%) m.p. 121-122 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5-Trichlorobenzotrifluoride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Rohm and Haas Company; US4330324; (1982); A;; ; Patent; Rohm and Haas Company; US4358308; (1982); A;; ; Patent; Rohm and Haas Company; US4419124; (1983); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 29671-92-9, name is Carbamimidic chloride hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Carbamimidic chloride hydrochloride

To a solution of the ethyl [2-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}-phenyl)cyclopropyl]acetate (Step 6, Example 1, 3.52 g, 0.01 mol) in dry dichloromethane (20 mL) was added 4N HCl in dioxane (12.5 mL, 0.05 mol). The solution was stirred at room temperature for 2 hours and solvent evaporated to give white solid as HCl salt. To a solution of carbamidic chloride hydrochloride (2.03 g, 0.0176 mol) in acetonitrile (30 mL) and triethylamine (11 mL) was added crude amine (2.75 g, 0.0088 mol) in acetonitrile (20 mL). The reaction mixture was refluxed overnight and solvent concentrated to give solid residue used without further purification. The mass spectrum was consistent with the proposed structure. M+=320.

The synthetic route of Carbamimidic chloride hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nagarajan, Srinivasan R.; Khanna, Ish Kumar; Clare, Michael; Gasiecki, Alan; Rogers, Thomas; Chen, Barbara; Russell, Mark; Lu, Hwang-Fun; Yi, Yu; Huff, Renee M.; Desai, Bipinchandra N.; Devadas, Balekudru; Parikh, Mihir D.; Penning, Thomas; US2004/92538; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 26487-67-2

Example 2: Synthesis of 2-((2-(azepan-1-yl)ethoxy)methyl)pyrazolo[1 ,5-a]pyridine maleate 0.12 g (3 mmol) of a 60percent NaH suspension in mineral oil were added under nitrogen to a solution of pyrazolo[1 ,5-a]pyridin-2-ylmethanol (100 mg, 0.67 mmol) in 5 mL of dry THF. The mixture was stirred for 5 h at room temperature, and after this time, was added 1 -(2-chloroethyl)azepane hydrochloride (201 mg, 1 .01 mmol) suspended in 8 ml_ of THF with 200muIota of triethylamine (TEA). The mixture was heated at 55 5C for 18 h, allowed to cool to room temperature, quenched with water and extracted with EtOAc, and washed with water. The organic layers were dried over Na2S04 and concentrated under vacuum to afford 0.22 g (65percent) of brown oil. Maleate salt was obtained following the same procedure as for example 1 . 1 H NMR (CDCI3) delta ppm: 8.42 (d, J = 6.8 Hz, 1 H), 7.52 (d, J = 8.8 Hz, 1 H), 7.20 – 7.06 (m, 1 H), 6.78 (t, J = 6.9 Hz, 1 H), 6.49 (s, 1 H), 6.30 (s, 2H), 4.74 (s, 2H), 4.08 – 3.89 (m, 2H), 3.70 – 3.51 (m, 2H), 3.36 – 3.25 (m, 2H), 3.19 – 2.99 (m, 2H), 2.15 – 1 .92 (m, 2H), 1 .92 – 1 .72 (m, 4H), 1 .72 – 1 .54 (m, 2H).

The synthetic route of 26487-67-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE S.A.; DIAZ FERNANDEZ, Jose Luis; CUBERES ALTISENT, Ma Rosa; WO2013/124341; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

16793-91-2, name is 2-Chlorophenethyl Bromide, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: chlorides-buliding-blocks

Example 51 Preparation of 6-(2-chlorophenethyl)-9-chloro-1.2.3.4.5.6-hexahvdro-3- methylazepmor4.5-b1mdole (Compound No 29)[0416] The title compound was prepared by following general procedure 4 9-Chloro-6-(2- chlorophenethyl)-3-methyl-l,2,3,4,5,6-hexahydroazepmo[4,5-b]mdole 9-chloro-3-methyl- l,2,3,4,5,6-hexahydroazepmo[4,5-b]mdole (0 234 g,l mmol) along with tetrabutylammomum chloride (0 026 g, 0 094 mmol) were taken into 50% aq NaOH solution (4 mL) and stirred for 15 mm at RT, l-(2-bromoethyl)-2-chlorobenzene (0 878 g, 4 mmol) was added and stirred for 10 mm at RT and then the reaction mixture was heated at 100 0C for overnight Product detected by LCMS The product was extracted in ethyl acetate, dried over anhydrous sodium sulfate, concentrated and purified by reverse phase chromatography to get pure compound 9- chloro-6-(2-chlorophenethyl)-3-methyl-l,2,3,4,5,6-hexahydro azepmo[4,5-b]mdole as the TFA salt (70 mg)

The synthetic route of 16793-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David, T.; PROTTER, Andrew, Asher; JAIN, Rajendra, Parasmal; CHAKRAVARTY, Sarvajit; GIORGETTI, Marco; WO2010/51503; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., Recommanded Product: 5-(Chloromethyl)benzo[d][1,3]dioxole

4- (1,3_-benzodioxol-dioxan-5-methoxy) -2_ hydroxyacetophenone Synthesis[0078] In a 500mL three-necked flask, 3.0g (0.02mol) 2 , 4-hydroxyacetophenonewas dissolved in 150mL acetone, 0.8gKI, 2.0gK 2C03, a small amount of the TBAB,heated to reflux with stirring, slowly added dropwise containing 3.14g(0.02mol) 5_-chloro-methyl-1, 3 – benzodioxol dioxane acetone 150mL. Afterthe dropwise addition, it was refluxed for one hour, cooled, filtered offsolid, and concentrated to give a pale yellow solid which was recrystallizedfrom ethanol to give white needle crystals, 4.0g,

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Southeast University; Chi, Jin; Ji, min; (19 pag.)CN103539760; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-24-2, name is (2-Chloroethyl)benzene, A new synthetic method of this compound is introduced below., Safety of (2-Chloroethyl)benzene

To a solution of substituted hydrazine (3 mmol) and carbon disulfide (8 mmol) Triton-B (2 mmol) were slowly added while stirring at room temperature. The stirring was continued till 0.5 h after which required amount of alkyl halide (3 mmol) was added (Scheme-I). The reaction was further continued until the completion of reaction (Table-1) under argon. The obtained mixture was poured into water (20 mL) and the extraction of organic layer was done with EtOAc (3 ¡Á 10 mL). The organic layer was washed with 0.1 N hydrochloric acid (20 mL), sodium bicarbonate solution (25 mL), brine solution (30 mL) and dried sodium sulfate and concentrated to get the desired compound I. Later, the desired compounds were confirmed by IR, NMR and elemental analysis.

The synthetic route of 622-24-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zaidi, Sadaf; Saxena, Mridula; Asian Journal of Chemistry; vol. 31; 7; (2019); p. 1581 – 1584;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1435-48-9, name is 2,4-Dichloro-1-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435-48-9, category: chlorides-buliding-blocks

(S)-3-((R)-2-Ethoxy-1-hydroxyethyl)pyrrolidine-1-carboxylic acid t-butyl ester (25.0 mg, 96.4 mmol) was dissolved in DMF (200 muL). NaH (2776 mug, 115.7 mmol) was added and the mixture was stirred at room temperature for 15 minutes. 2,4-Dichloro-1-fluorobenzene (22.6 muL, 192.8 mumol) was added and the mixture was stirred at 70 C. for 3 hours. The mixture was concentrated then dissolved in 1.2M HCl in EtOH (1.0 mL, 1.2 mmol) and stirred overnight. The product was concentrated and purified by preparative HPLC (10-40%, 60 min, BDS) to yield the title compound as a mono-TFA salt oil (24.4 mg, 100% purity). MS m/z: [M+H]+ calcd for C14H19Cl2NO2, 304.08; found 304.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dichloro-1-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; STANGELAND, Eric; SCHMIDT, Jane; SAITO, Daisuke Roland; HUGHES, Adam; PATTERSON, Lori Jean; US2011/21597; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93-50-5, name is 4-Chloro-2-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks

General procedure: B. To a suspension of compound 7b (1 .69 g, 10.7 mmol, 1 eq) in concentrated HCl (25 mL) and acetic acid (10 mL) at 0 C was added a solution of sodium nitrite (740 mg, 10.7 mmol, 1 eq) in water (10 mL) dropwise. The suspension was warmed to 60 C for 1.5 hrs. The solution was cooled to 0 C and a solution of SnCl2 (5.32 g, 23.6 mmol, 2.2 eq) in concentrated HCl (25 mL) was added. After 30 minutes, a precipatate was collected by filtration to give compound 7c (2.06 g, 93%). 1H NMR (DMSO-d6) delta: 9.94 (br. s., 2H), 7.72 (br. s., 1H), 7.07 (s, 1H), 7.00 (s, 2H). 3.85 (s, 3H). Following the procedure described above for Example 7 and substituting the appropriate reagents, starting materials and purification methods known to those skilled in the art, the following intermediates to compounds of the present invention were prepared:

According to the analysis of related databases, 93-50-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; WINTERS, Michael, P.; SUI, Zhihua; WO2014/28805; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19230-27-4, name is 1,3-Dibromo-2-chlorobenzene, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

1,3-Dibromo-2-Chloro-Benzene 1eq(45.5g), 2-Aminophenylboronic acid 2eq (46.6 g), Tetrakis (triphenylphosphine) palladium (0) (Pd (PPh3) 4), 1-dibromo-2-chloro-5 mol% (9.82 g) and K2CO3 2eq (47.0 g) were suspended in toluene (12 times of solid content, 550 ml) and distilled water (5 times the amount of K2CO3, 235 ml) and refluxed under nitrogen stream for 18 hours. After completion of the reaction, the reaction mixture was extracted with toluene and distilled water. The organic layer was dried over magnesium sulfate (MgSO4), filtered and the filtrate was concentrated under reduced pressure. The organic solution was removed, and the residue was subjected to silica gel column chromatography with hexane: dichloromethane = 7: 3 (v / v), and the resulting solid was recrystallized from dichloromethane and acetone to obtain an intermediate a-1 (37 g, Y = 74%).

The synthetic route of 19230-27-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd; Jang Gi-po; Kim Jun-seok; Lee Seung-jae; Hong Jin-seok; Kim Chang-u; Jeong Seong-hyeon; Kim Yeong-gwon; Ryu Eun-seon; Jeong Ho-guk; (30 pag.)KR2017/111538; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 6529-53-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6529-53-9, name is 1-(2-Bromoethyl)-4-chlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 1.69: Preparation of (4-Bromo-l-methyl-lH-pyrazoI-3-yl)-{4-[2-(4-chloro- phenyl)-ethyl]-piperazin-l-yl}-methanone (Compound 2).A mixture of (4-bromo- 1 -methyl- lH-pyrazol-3 -yl)(piperazin- 1 -yl)methanone hydrochloride (40.0 mg, 0.146 mmol), l-(2-bromoethyl)-4-chlorobenzene (26 muL, 0.18 mumol) and potassium carbonate (61 mg, 0.44 mumol) in acetonitrile (2 mL) was heated at 150 C for 20 min under microwave irradiation in a heavy-walled sealed tube. The reaction mixture was purified by preparative EtaPLC. The corresponding fractions were collected, and lyophilized to afford the TFA salt of the title compound (7.9 mg) as a white solid. Exact mass calculated for C17H20BrClN4O: 410.1; Found: LCMS m/z (%) = 411.1 (M+H+ 79Br, 77%), 413.1 (M+H+ 81Br, 100%).;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(2-Bromoethyl)-4-chlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2008/42388; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics