Adding a certain compound to certain chemical reactions, such as: 210532-25-5, name is 3,5-Difluorobenzene-1-sulfonyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 210532-25-5, name: 3,5-Difluorobenzene-1-sulfonyl chloride
At room temperature,2-methyl-4-carbonyl-6,7,8,9-tetrahydropyrido [1,2-a] thiophene [2,3-d] pyrimidin-3-amine hydrochlorideCompound 10 (0.31 g, 1 mmol) was dissolved in anhydrous dichloromethane (10 ml)Followed by the addition of 3,5-difluorobenzenesulfonyl chloride (0.23 g, 1.1 mmol)Triethylamine (0.12 g, 1.2 mmol) was slowly added with stirring, stirred at room temperature overnight,Reaction to the material completely disappeared,Dichloromethane, concentrated, using a 5: 1 by volume petroleum ether: ethyl acetate column chromatography gradient elution,To give compound 10f; yield: 82% as a white solid
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Difluorobenzene-1-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chinese Academy Of Sciences Xinjiang Physics And Chemistry Technology Institute; A Jiaikebaier¡¤aisa; Nie Lifei; Huang Guozheng; (23 pag.)CN106749317; (2017); A;,
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