Reference of 452-73-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 452-73-3 name is 2-Chloro-4-fluoro-1-methylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 1 Preparation of 2-chloro-4-fluorobenzyl bromide A solution of bromine (7.10 ml) in carbon tetrachloride (70 ml) was added slowly over a period of 3 hours to a solution of 2-chloro-4-fluorotoluene (20.0 g) in carbon tetrachloride (80 ml) maintained at the reflux temperature and irradiated by light from a tungsten lamp (200 watt). After the addition was completed the mixture was heated at the reflux temperature with irradiation until the colour had been discharged (ca.1 hour). The solvent was then removed by evaporation under reduced pressure and the residual oil distilled to yield 2-chloro-4-fluorobenzyl bromide (80% pure, 18.0 g) b.p. 110-120 C./15 mm Hg.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-4-fluoro-1-methylbenzene, and friends who are interested can also refer to it.
Reference:
Patent; Imperial Chemical Industries PLC; US4567199; (1986); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics