Reference of 1005-56-7,Some common heterocyclic compound, 1005-56-7, name is O-Phenyl carbonochloridothioate, molecular formula is C7H5ClOS, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(Scheme 1) to 500 mg (1.49mmol) fluorescent dye, 516 mg (2.98mmol) sulfur generation of chlorine phenyl formate (384 mg, 2 . 98mmol) and N, N – diisopropylethylamine (DIPEA) dissolved in 15 ml dichloromethane in, then 25 C stirring reaction under 9h, after steaming and to get the crude product, last-used methylene chloride: methanol=60:1 system carrying out column chromatography separation, get the pure product 647 mg, and the yield is 92
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route O-Phenyl carbonochloridothioate, its application will become more common.
Reference:
Patent; University of Jinan; Wang, Yawei; Zhang, Meng; Wu, Liu; Liu, Caiyun; Duan, Qingxia; Wang, Zuokai; Zhu, Baocun; (12 pag.)CN106543097; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics