2729-34-2, name is 3,5-Dichloro-4-fluoroaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H4Cl2FN
(3,5-Dichloro-4-fluoro-phenyl)-[l-(4-methoxy-benzyl)-5-morpholin-4-yl-lH-[l,2,4]triazol-3- yl] -amine – In a 2-5 mL microwave vial, 4-(3-bromo-l-(4-methoxybenzyl)-lH-l,2,4-triazol-5-yl)morpholine (133.5 mg, 378 muiotaetaomicron, Eq: 1.00), 3,5-dichloro-4-fluoroaniline (81.6 mg, 454 muiotaetaomicron, Eq: 1.20), sodium tert-butoxide (109 mg, 1.13 mmol, Eq: 3.00), tris(dibenzylideneacetone)dipalladium (0) (20.8 mg, 22.7 muiotaetaomicron, Eq: 0.06) and di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (38.5 mg, 90.7 muiotaetaomicron, Eq: 0.24) were combined. The system was evacuated and recharged with nitrogen (2x). Toluene (1.08 ml) was then added. The mixture was stirred at room temperature for 5 minutes and then heated at 85C for 15 h. After cooling to room temperature, the reaction mixture was partitioned between EtOAc and water. The organic layer was removed, washed with brine, dried (Na2S04) and concentrated over celite. The crude material was purified by flash chromatography (silica gel, SF15-24 g, 20% to 100% EtOAc in hexanes) to gove 90 mg (53%) of desired product.
The synthetic route of 2729-34-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DING, Qingjie; JIANG, Nan; WEIKERT, Robert James; WO2014/135472; (2014); A1;,
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