Adding a certain compound to certain chemical reactions, such as: 874-17-9, name is 4-Chloro-2,6-dibromoaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 874-17-9, SDS of cas: 874-17-9
Pd(OAc)2 (0.01 g, 0.04 mmol), 2,6-dibromo-4-chlorobenzenamine (0.57 g, 2 mmol), K2CO3 (0.55 g, 4 mmol) and phenylboronic acid (0.54 g, 4.4 mmol) were placed in a 100 ml flask and allowed to stir at 25 C for 24 h, in the presence of 10 ml PEG-400. The mixture was extracted three times with 10 ml diethyl ether. The combined organic phase was dried over MgSO4, filtered, and the solvent was removed. The residue was purified by chromatography on silica gel with petroleum ether/ethyl ester (v/v = 20:1) to give 4-chloro-2,6-diphenylbenzenamine (0.34 g, 60% yield). 1H NMR (400 MHz, CDCl3): delta 3.71 (s, 2H, -NH2), 7.00 (s, 2H, benzenamine), 7.28 (t, 2H, phenyl ring), 7.33-7.40 (m, 8H, phenyl ring). 13C NMR (400 MHz, CDCl3): delta 124.82 (benzenamine carbon connected with Cl), 127.47 (benzenamine carbon connected with phenyl), 128.38 (benzenamine carbon near Cl), 128.98 (phenyl carbon), 129.58 (phenyl carbon near benzenamine), 130.46 (phenyl carbon), 138.46 (phenyl carbon connected with benzenamine), 139.74 (benzenamine carbon connected with NH2).
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Reference:
Article; Yuan, Jianchao; Wang, Fuzhou; Yuan, Bingnian; Jia, Zong; Song, Fengying; Li, Jing; Journal of Molecular Catalysis A: Chemical; vol. 370; (2013); p. 132 – 139;,
Chloride – Wikipedia,
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