In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 932-32-1, name is 2-Chloro-N-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-Chloro-N-methylaniline
Weigh BTC (58mg, 0.2mmol) in a 25mL two-neck bottle.Add 5 mL of anhydrous dichloromethane, magnetically stir, add equivalents of N-methyl-o-chloroaniline, triethylamine (0.25 mmol) and 5 mL of dichloromethane in a 25 mL constant pressure dropping funnel.Under the ice bath,Slowly add dropwise, remove the ice salt bath after the end of the addition, and stir at room temperature for 4 h.HZA (40 mg, 0.1 mmol) was added to a 10 ml vial, and traces of DMAP, 5 mL of dichloromethane were added, and magnetically stirred at room temperature until completely dissolved. The solution was slowly added dropwise to the above reaction solution under ice salt bath, and the ice salt bath was removed by dropwise addition, and stirred at room temperature. After the reaction is completed, 3 to 6 times the volume of the reaction liquid is added to the above reaction liquid, and distilled water is added.The organic layer was extracted with EtOAc (EtOAc) (EtOAc m.The crude product was then eluted with a petroleum ether:ethyl acetate volume ratio of 20:1 in a mixed solvent, and a thin layer was detected to collect an eluent having a strong ultraviolet at 254 nm and a polarity less than HZA.The combined eluate and the product obtained by evaporating the solvent under reduced pressure are dried to obtain HZAM-12.The yield was 88%.
The synthetic route of 932-32-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University of Technology; Zhan Zhajun; Shan Weiguang; Chen Yan; Shu Renhuan; Wang Jianwei; Ma Liefeng; (31 pag.)CN109956952; (2019); A;,
Chloride – Wikipedia,
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