Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 62356-27-8, name is 1-Bromo-3-chloro-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Bromo-3-chloro-2-methylbenzene
Embodiment 48 (S,E)-2-(2,6-Dimethoxy-4-(2-(4′-methoxy-2-methylbiphenyl-3-yl)vinyl)benz ylamino)-3 -hydroxypropionic acid 48 Synthetic route Synthesis of compound 48-c 2-Bromo-6-chlorotoluene (8.0g, 38.93mmol) and vinylboronic acid pinacol ester (7.3g, 46.72mmol) were dissolved in toluene (100mL), followed by addition of bis(tri-tert-butylphosphine)palladium (1.4g, 2.73mmol) and triethylamine (35.52g, 311.44mmol). After the reaction system was purged three times with nitrogen, the reaction solution was heated to 80C and stirred for 16 hours. Then the reaction solution was cooled to room temperature, diluted with ethyl acetate (100mL), washed successively with water (100mL x 3) and saturated brine (100mL). The organic phase was dried over anhydrous sodium sulfate. The residue was purified by silica gel column chromatography (petroleum ether) to give compound 48-c (7.19g, yield 65.8%). 1H NMR (400 MHz, CDCl3) delta: 7.66-7.61 (d, J = 23.0Hz, 1H), 7.42-7.41 (d, J = 9.5Hz, 1H), 7.32-7.30 (d, J = 9.5Hz, 1H), 7.13-7.09 (t, 1H), 6.06-6.02 (d, J = 22.5Hz, 1H), 2.45 (s, 3H), 1.32 (s, 12H) ppm.
According to the analysis of related databases, 62356-27-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangzhou Maxinovel Pharmaceuticals Co., Ltd.; WANG, Yuguang; XU, Zusheng; WU, Tianzhi; HE, Min; ZHANG, Nong; (113 pag.)EP3483142; (2019); A1;,
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