Some common heterocyclic compound, 2106-02-7, name is 2-Chloro-4-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2106-02-7
General procedure: The synthesis of azides were carried out according to the publish procedure [59]. Briefly, aniline (1eq) was dissolved in6N HCl solution (10mL/mmol of aniline) at room temperature and cooled up to 0C, followed by addition of aqueous NaNO2 (1eq) solution under stirring. After 10min of stirring at same temperature, sodium azide (1.2eq) was added to the reaction mixture. This mixture was further stirred at room temperature for 2-3h. The reaction was worked up by extraction with chloroform. The organic layer was washed with brine solution and dried over Na2SO4. After evaporation of the solvent, the crude product (3a-r) was pure enough for further reactions. All the synthesized azides were stored at-20C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2106-02-7, its application will become more common.
Reference:
Article; Kant, Rama; Singh, Vishal; Nath, Gopal; Awasthi, Satish Kumar; Agarwal, Alka; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 218 – 228;,
Chloride – Wikipedia,
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