Synthetic Route of 19752-55-7,Some common heterocyclic compound, 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, molecular formula is C6H3BrCl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a nitrogen environment, it was dissolved in I-31(32 g, 59.8 mmol) and 250 mL THF, here the 1-bromo-3,5-dichlorobenzene(16.2 g, 71.7 mmol) and tetrakis (triphenylphosphine) put the palladium (0.69 g, 0.60 mmol) was stirred. Into a potassium carbonate (20.7 g, 150 mmol) in saturated water was heated to reflux at 80 ¡ã C for 13 hours. After the reactionwas completed, the reaction solution into water and extracted with DCM then water was removed with anhydrous MgSO4,filter and was concentrated under reduced pressure. Thus the resulting residue was separated and purified by flash columnchromatography to obtain the compound I-32(25.9 g, 78percent).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3,5-dichlorobenzene, its application will become more common.
Reference:
Patent; Cheil Industries Co., Ltd; Lee, Han Ir; Yu, Uhn Sun; Kang, Dong Min; Kang, Uii Soo; Yang, Yong Tak; Oh, Jae Jin; Yu, Dong Gyu; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; Hong, Jin Suk; (59 pag.)KR2015/6758; (2015); A;,
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