Reference of 62356-27-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62356-27-8, name is 1-Bromo-3-chloro-2-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of l-bromo-3-chloro-2-methylbenzene (2.74 g, 12.39 mmol) in THF (40 ml.) at -70 C was added n-BuLi (1.6 M in hexane) (7.75 ml_, 12.39 mmol) drop wise over 5 min by syringe along the wall of the flask. After adding, the reaction was stirred at this temperature for 30 min. Then the resulting solution was added into a solution of (S)-tert-butyl l,6-dioxohexahydropyrrolo[l,2-a]pyrazine-2 (1H) -carboxylate (3 g, 11.8 mmol) in THF (40 ml_). After stirred at -70C for 5 min, the reaction mixture was quenched with saturated NH4CI and extracted with EtOAc (2 x 20 ml_), washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography to give the title compound (3.6 g, yield : 80%); m/z (ES+) : 381 [M + H] + .
The synthetic route of 1-Bromo-3-chloro-2-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LEO PHARMA A/S; BLADH, Haakon; FELDING, Jakob; ZHOU, Ding; CAI, Zhen-wei; S?RENSEN, Morten Dahl; WO2015/24878; (2015); A1;,
Chloride – Wikipedia,
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