Adding a certain compound to certain chemical reactions, such as: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-42-9, Quality Control of 2-Methoxyethyl chloride
KOH (1.12 g, 20 mmol) was added to a flask equipped with benzimidazole (2.36 g, 20 mmol) and acetonitrile (20 mL). The mixture was then stirred at room temperature for 1 h before adding 2- chloroethyl methyl ether (1.90 g, 20 mmol) slowly. The mixture was then heated at 76 C for 17 h. The reaction mixture was cooled to room temperature. All volatiles were removed by vacuum. The residue was added with water (20 mL). The aqueous solution was extracted by chloroform (3 x 30 mL). The organic layers were collected, washed by water (2 x 20 mL) and dried by MgS04. The solvent was removed by vacuum to obtain ligh-yellow oil (2.80 g, 80%). The characterization data were identical to those literature values (Ozdemir, I.; Sahin, N.; Gok, Y.; Demir, S.; Cetinkaya, B. J. Mol Catal. A: Chem. 2005, 234, 181. and Denton, J. R. Synthesis 2010, 775-782).
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Reference:
Patent; THE GOVERNING COUNCIL OF UNIVERSITY OF TORONTO; LANXESS Deutschland GmbH; MUELLER, Julia Maria; STEPHEN, Douglas; LUND, Clinton; SGRO, Michael; ONG, Christopher; CARIOU, Renan; WO2013/24119; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics