Electric Literature of 72235-56-4, A common heterocyclic compound, 72235-56-4, name is 3-Chloro-4-fluorobenzylamine, molecular formula is C7H7ClFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 50 mL shaker vessel was added 2,6-dimethoxy-4- polystyrenebenzyloxy-benzaldehyde (DMHB resin) (2 g, 1.5 mmol/g, 3 mmol) and 25 mL of NMP. 3-Chloro-4-fluorobenzylamine (1.92 g, 12 mmol), HOAc (2.5 mL, 10%), and Na (OAc) 3BH (3.18 g, 15 mmol) were then added. The mixture was shaken at rt for overnight. The resutling resin was washed with NMP (25 mL x 2), DCM (25 mL x 2), MeOH (25 mL x 2) and DCM (25 mL x 2) and dried in vacuum oven at 35 C for overnight to yield DMHB resin-bound 3-chloro-4- fluorobenzylamine.
The synthetic route of 72235-56-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2005/87236; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics