Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 697-86-9, name is 2-Bromo-4,6-dichloroaniline, A new synthetic method of this compound is introduced below., Quality Control of 2-Bromo-4,6-dichloroaniline
To a toluene solution (8 mL) of 2-bromo-4,6-dichloroaniline (1 g) (CAS registry number: 697-86-9), 4-fluorophenyl acetyl chloride (788 mg) was added, followed by stirring at 90 C. overnight. The reaction mixture was cooled to room temperature, and precipitate was filtered. The precipitate was washed with toluene and then dried under reduced pressure at 50 C. to obtain the title compound (1.28 g) having the following physical property values. TLC: Rf 0.43 (hexane:ethyl acetate=1:1); 1H-NMR (CD3OD): delta 3.72, 7.02-7.08, 7.38-7.43, 7.58, 7.69.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Ono Pharmaceutical Co., Ltd; YASHIRO, Kentaro; WAKAMATSU, Daisuke; SAITO, Tetsuji; (53 pag.)US2017/217888; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics