Related Products of 202197-26-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202197-26-0, name is 3-Chloro-4-((3-fluorobenzyl)oxy)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The compound (IV) (15 g, 66.65 mmol) and thionyl chloride (30 mL) were stirred and slowly added dropwiseDMF (5.36 g, 73.32 mmol). After completion of the dropwise addition, stirring was continued and the temperature was raised to 80 C,The reaction was completed after 2 h. Cooled to room temperature, under reduced pressure to remove the vast majority of thionyl chloride and DMF, and then add 40mLToluene was continuously distilled under reduced pressure to give the compound (V), without further purification, directly to another (30 mL) and compound (VI) (17.61 g, 69.98 & lt; RTI ID = 0.0 & gt; mmol), stir well after the temperature to reflux, 1h after the reaction is completed. Cooling, filtering, washing with a small amount of methanol (3-fluorobenzyl) oxy] phenyl] -6-bromo-quinazolin-4-amine (VII) (25.38 g, 83%).
The synthetic route of 3-Chloro-4-((3-fluorobenzyl)oxy)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Tianci Biological Gu Biological Engineering Co., Ltd.; Li Hanpu; Li Jianzhi; Liu Hai; Chi Wangzhou; Zhai Zhijun; Li Jianxun; (14 pag.)CN106632276; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics