In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3972-56-3 as follows. name: 1-tert-Butyl-4-chlorobenzene
100 ml of 60% nitric acid was added dropwise to 100 ml of 95% sulfuric acid, at a temperature of 35C or less, under ice-cooling, to prepare a mixed acid solution. 100 g (0.593 mol) of 4-tert-butylchlorobenzene (A-1) was added dropwise to this mixed acid solution, at a temperature of 30C or less, followed by after-reaction (20 to 25C) for 2.5 hours. The reaction solution was poured into cold water, and it was then extracted with 100 ml of toluene, followed by washing with water, to obtain a toluene solution of (A-2).
According to the analysis of related databases, 3972-56-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; FUJI PHOTO FILM CO., LTD.; EP1535898; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics