Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 118-69-4, name is 2,6-Dichlorotoluene, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks
(1) In a 1000 ml four-necked flask,300 g of dimethylsulfoxide was added in this order,2,6-dichlorotoluene 100 g (0.62 mol)Heating up,When the temperature reaches 160 C,Dropping 200 gMethanol sodium methoxide solution (sodium methoxide content 28%, 1.04 mol)Methanol was added dropwise,Insulated at 160 C for 8 h.(2)Cooling to 80 ,0.1 g of catalyst PEG-600 (polyethylene glycol 600) was added,At this temperature, 20 g of methyl chloride (0.40 mol) was passed until the mass fraction of 6-chloro-2-hydroxytoluene was less than 1%, and the reaction was carried out for 2 hours.(3) cool to room temperature,And then negative pressure recovery DMSO,After treatment, 96.8 g of 6-chloro-2-methoxytoluene was obtained, the content was 96.0% and the yield was 95.6%.
The synthetic route of 118-69-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu Yangnong Chemical Industry Co., Ltd; Jiangsu Youjia Plant Protection Co., Ltd; Zhou, Qikui; Jiang, Youfa; Zhu, Jianrong; Sun, Bing; Wang, Mingkun; Kuan, Jianbo; Xue, Yadong; (5 pag.)CN106518630; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics