Related Products of 104-11-0, These common heterocyclic compound, 104-11-0, name is 1-(4-Chlorophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 46: To a solution of Example 45 (30 mg, 75.9 umol, 1 eq) in CH3CN (1 mL) was added TMSC1 (24.7 mg, 227.6 umol, 28.8 uL, 3 eq) and Nal (34.1 mg, 227.6 umol, 3 eq) successively. The mixture was stirred at 25 C for 15 min. l-(4-chlorophenyl)-N-methyl- methanamine (18.9 mg, 121.4 umol, 1.20 eq) was then added and stirring continued for a further 10 min. NaBH(OAc)3 (64.3 mg, 303.5 umol, 3 eq) was added and stirring continued for 2 hours. The residue was diluted with water (10 mL) and extracted with EtOAc (5 mL *3). The combined organic layers were dried and the solvent removed in vacuo to afford the crude product. The crude product was purified by Prep-TLC on silica gel to give the target compound as a yellow solid (30 mg, 58.5%). LCMS MH+ calculated, 507.2, found, 507.2. 1H MR (400MHz, CD3OD) delta 8.81 – 8.71 (m, 1H), 8.19 (br s, 1H), 7.86 (br d, J=4.4 Hz, 1H), 7.54 – 7.46 (m, 8H), 7.39 (d, J=8.4 Hz, 2H), 4.75 (br t, J=6.8 Hz, 2H), 4.21 (s, 4H), 4.06 (s, 2H), 4.00 – 3.93 (m, 3H), 3.21 – 3.12 (m, 2H), 3.05 – 2.92 (m, 4H).
The synthetic route of 104-11-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHRYSALIS, INC.; GWALTNEY, Stephen; (167 pag.)WO2017/143011; (2017); A1;,
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