Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 13078-79-0
Example 4; [0215] 14-[2-(3-Chlorophenyl)ethylearbamoyllthiazol-2-ylmethyllcarbamic acid tert- butyl ester: 2- (Boc-aminomethyl)thiazole-4-carboxylic (0.5 g, 1.9 mmol) and HATU (0.81 g, 2.1 mmol) were weighed into a flask. DMF (7 mL) and DIEA (0.68 mL, 3.9 mmol) were added. The mixture was stirred for 10 minutes. 2-(3- Chlorophenyl)ethylamine (0.3 g, 1.9 mmol) was added and reaction mixture was stirred for 12 hours. The mixture was diluted EtOAc and water. The layers were separated and the aquous layer was extracted with 3 x EtOAc. The combined organic layers were washed with 5% aqueous lithium chloride and brine, dried over sodium sulfate, filtered, and concntrated in vacuo. The material was purifed by filtration through a plug of silica gel with 1: 1 EtOAc: hexane to afford the title compound (0.73 g, 95%) : 1H NMR (400 MHz, d6-DMSO) : 8.42 (t, 1H), 8.10 (s, 1H), 7.85 (t, 1H), 7.27 (m, 3H), 7.16 (m, 1H), 4.38 (d, 2H), 3.46 (q, 2H), 2.82 (t, 2H), 1.39 (s, 9H) ; MS (ESI-LCMS) for C14H14ClN3O3S: 340 (MH-tBu+).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13078-79-0.
Reference:
Patent; EXELIXIS, INC.; WO2005/97765; (2005); A1;,
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