Synthetic Route of 220227-21-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 220227-21-4 name is 2,4,5-Trifluorobenzene-1-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of the N-(2,4-dimethoxybenzyl)pyri-midin-4-amine(0.76 g, 3.10 mmol) prepared in Example la and l,4-diazabicyclo[2.2.2]octane(0.70 g, 6.20 mmol) in acetonitrile (20 mL), 2,4,5-trifluorobenzenesulfonylchloride (1.43 g, 6.20 mmol) was added with cooling on ice, and thereaction solution was stirred at room temperature for 1 hour. The reactionsolution was filtered, the filtrate was concentrated under reduced pressure,and the residue was purified with silica gel chromatography (hexane/ethylacetate=67:33) to yield the title compound (0.72 g, 53%) as a colorless solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4,5-Trifluorobenzene-1-sulfonyl chloride, and friends who are interested can also refer to it.
Reference:
Patent; Daichi Sankyo Corporation; Takahashi, Sakiko; Domon, Yuki; Kitano, Yutaka; Sinojika, Tsuyoshi; (102 pag.)KR2015/126620; (2015); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics