Reference of 108-41-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 108-41-8, name is 1-Chloro-3-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
m-chlorotoluene (5.1 g, 40 mmol),sodium bromate (4.6 g, 30.6 mmol),sodium bromide (6.3 g, 61.2 mmol), 1,2-dichloroethane (25 mL) was added to a reaction flask equipped with a stirred, reflux condenser, thermometer and tail gas absorber, heated to reflux and rapidly added 1/3 of the total volume of the initiator solution (0.15 g AIBN, dissolved (5 g) was slowly added dropwise with sulfuric acid (4.6 g, 46 mmol concentrated sulfuric acid diluted with 2 mL of water) and the remaining initiator solution was followed by gas chromatography. After completion of the reaction, the reaction was cooled to At room temperature, saturated sodium bisulfite solution (10mL) was added and stirred to red to fade. The mixture was allowed to stand, and the aqueous phase was extracted twice with 1,2-dichloroethane (10 mL x 2). The organic phases were combined and washed with saturated chlorine Sodium chloride solution washing, dry.The crude product was purified by column chromatography (elution solvent as petroleum ether) to give 10.2 g of m-chlorobenzyl dibromide in 90% yield.The product was a colorless liquid
The synthetic route of 1-Chloro-3-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang Normal University; Xiao Xiaohui; Chen Yufeng; (12 pag.)CN107098791; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics