Some common heterocyclic compound, 118754-53-3, name is 4-Bromo-3,5-dichlorobenzotrifluoride, molecular formula is C7H2BrCl2F3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 118754-53-3
2.08 g of 2-bromo-1,3-dichloro-5-(trifluoromethyl)benzene (0.01 mol) was added to the reaction flask. 4.9 g of 5-amino-4-((trifluoromethyl)thio)-1H-pyrazole-3-carbonitrile (0.017 mol), 64 mg of copper (10 mol%), 0.27 g 1,10-phenanthroline (15 mol %), dissolved in 15 ml of THF and 5 ml of DMSO, reacted at 60 C for 8 hours. After the reaction is finished, the extract is dried and dried. The crude compound 1 was obtained in a mass of 3.6 g; after the obtained Compound 1 and 20 ml of dichloromethane were uniformly mixed, slowly add 1.7 g of benzoyl peroxide (0.013 mol) at 0 C. After the dropwise addition, the reaction was carried out for 2 hours at room temperature. After the reaction is finished, the extract is dry, purification afforded 3.5 g of fipronil in a yield of 82%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 118754-53-3, its application will become more common.
Reference:
Patent; Jiangsu Changqing Agrochemical Co., Ltd.; Yu Guoquan; Sun Xialin; Ma Changqing; Ding Huaping; (5 pag.)CN109134375; (2019); A;,
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