10061-02-6, name is trans-1,3-Dichloropropene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 10061-02-6
PREPARATION OF DIAZOKETONE (4C)Ester (2a) (4.3 g, 28 mmol) was added to a solution of sodium hydride (60% dispersion in mineral oil, 1.4 g, 36 mmol) in DMF (50 mL) at 0 C. The mixture was stirred for 10 min before the addition of 1,3-dichloro-1-propene (1:1 E,Z-mixture, 92%, 4.1 mL, 42 mmol) and warmed to r.t. After 4 h, the reaction was quenched by addition of sat. NH4Cl solution (20 mL), and the reaction mixture was extracted with Et2O (100 mL*2). The organic phase was washed with brine (50 mL), dried over MgSO4, filtered and concentrated. Purification of the residue by flash column chromatography (hexanes-EtOAc, 3:1) gave methyl ester (4a) (1.8 g, 30%).Rf 0.53 (hexanes-EtOAc, 1:1). 1H NMR (500 MHz, CDCl3): d 6.19 (dt, J=1.2, 13.2 Hz, 1H), 5.94 (dt, J=7.9, 13.3 Hz, 1H), 3.85 (s, 3H), 3.16 and 3.02 (ABq, J=18.2 Hz, 2H), 2.67 2.56 (m, 2H), 2.21 (s, 3H). 13C NMR (125 MHz, CDCl3): d 202.7, 168.6, 125.5, 123.7, 118.2, 54.1, 48.9, 44.6, 38.1, 29.6.
The synthetic route of 10061-02-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SNU R&DB FOUNDATION; US2011/28741; (2011); A1;,
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