Related Products of 69695-61-0, These common heterocyclic compound, 69695-61-0, name is 2-Chloro-4-(trifluoromethoxy)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
An aqueous solution of 2-chloro-4-(trifluoromethoxy)phenylamine (9.0 g) was cooled at 0C, and concentrated hydrochloric acid (75 mL) was dropped slowly to its solution. The reaction mixture was stirred for 30 minutes, and sodium nitrite (3.73 g) was added to the reaction mixture. The reaction mixture was stirred for 40 minutes. An aqueous mixture solution of copper cyanide (4.65 g) and sodium cyanide (7.08 g) which been cooled off in 0C was added to the reaction mixture, and the reaction mixture stirred at room temperature for an hour. The reaction mixture was poured into 5N aqueous solution of sodium hydroxide which been cooled with ice, and extracted twice with ethyl acetate. The organic layer was washed by a saturated aqueous solution of sodium chloride, and dried with anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure. The obtained residue was purified by column chromatography on silica gel (high flash-SI, size 4L (made in Yamazen corporation), n-hexane?ethyl acetate/n-hexane=1/8) to obtain a title compound (7.36 g) having the following physical data. TLC:Rf 0.50 (n-hexane/ethyl acetate=20/1); 1H-NMR(CDCl3): delta 7.18 (m, I H), 7.37 (m, 1 H), 7.72 (d, J=8.6 Hz, 1 H).
The synthetic route of 69695-61-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ONO Pharmaceutical Co., Ltd.; EP2154139; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics