Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, A new synthetic method of this compound is introduced below., Recommanded Product: 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
99A. Preparation of 2,4-dichloropyrrolo[1,2-f][1,2,4]triazine-7-carbaldehyde To a solution of POCl3 (1.24 mL, 13.3 mmol) at 0 C. was added DMF (0.52 mL, 6.6 mmol) and the reaction was stirred until gas evolution subsided. The reaction was then warmed to ambient temperature and 2,4-dichloropyrrolo[1,2-f][1,2,4]triazine (250 mg, 1.33 mmol) was added as a solid in one portion. The reaction was warmed to 95 C. and stirred for five hours, then cooled to room temperature. The mixture was poured into ice cold 1:1 saturated aqueous NaHCO3/CH2Cl2 (50 mL). The layers were separated and the aqueous layer extracted with CH2Cl2 (3*25 mL). The combine organic layers were dried (Na2SO4), filtered and concentrated. The crude product was purified by flash chromatography (SiO2,40 g column, 50% CH2Cl2/Hexanes to 75% CH2Cl2/Hexanes, 25 minute gradient) to afford the desired product as a powder (170 mg, 60%). 1H-NMR (DMSO) delta 10.3 (s, 1H), 7.68 (d, 1H, J=4.8 Hz), 7.32 (d, 1H, J=4.8 Hz. HPLC tR=2.35 min (YMC S5 Combiscreen ODS 4.6*50 mm, 10-90% aqueous methanol containing 0.2% H3PO4, 4 min gradient, monitored at 254 nm).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Bristol-Myers Squibb Company; US2008/45496; (2008); A1;,
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