16793-91-2, name is 2-Chlorophenethyl Bromide, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: chlorides-buliding-blocks
Example 51 Preparation of 6-(2-chlorophenethyl)-9-chloro-1.2.3.4.5.6-hexahvdro-3- methylazepmor4.5-b1mdole (Compound No 29)[0416] The title compound was prepared by following general procedure 4 9-Chloro-6-(2- chlorophenethyl)-3-methyl-l,2,3,4,5,6-hexahydroazepmo[4,5-b]mdole 9-chloro-3-methyl- l,2,3,4,5,6-hexahydroazepmo[4,5-b]mdole (0 234 g,l mmol) along with tetrabutylammomum chloride (0 026 g, 0 094 mmol) were taken into 50% aq NaOH solution (4 mL) and stirred for 15 mm at RT, l-(2-bromoethyl)-2-chlorobenzene (0 878 g, 4 mmol) was added and stirred for 10 mm at RT and then the reaction mixture was heated at 100 0C for overnight Product detected by LCMS The product was extracted in ethyl acetate, dried over anhydrous sodium sulfate, concentrated and purified by reverse phase chromatography to get pure compound 9- chloro-6-(2-chlorophenethyl)-3-methyl-l,2,3,4,5,6-hexahydro azepmo[4,5-b]mdole as the TFA salt (70 mg)
The synthetic route of 16793-91-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David, T.; PROTTER, Andrew, Asher; JAIN, Rajendra, Parasmal; CHAKRAVARTY, Sarvajit; GIORGETTI, Marco; WO2010/51503; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics