Adding a certain compound to certain chemical reactions, such as: 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1996-29-8, name: 1-Bromo-4-chloro-2-fluorobenzene
1-bromo-4-chloro-2-fluorobenzene (5 g, 23.9 mmol, 1 equiv), piperazine-1 carboxylic acid tert- butyl ester (5.3 g, 1.15 eq), tris dibenzylideneacetone dipalladium (O) ( 0.43 g, 0.05 equiv), rac-BINAP (0.89g, 0.15 eq), sodium tert- butoxide (3.2 g, 1.4 eq) was slurried in toluene (60 mL), and heated overnight the mixture at 65 C.. After cooling to room temperature, it was added ethyl acetate (100mL). The black precipitate was removed by filtration. The filtrate was washed twice with 3N potassium carbonate solution. The organic phase was dried over sodium sulfate, concentrated and treated with 4NHCl in dioxane. The solid was collected by filtration, washed with ether, and dried under high vacuum 1- (4-chloro-2-fluorophenyl) piperazine was obtained as a dihydrochloride salt.
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Reference:
Patent; CHEMOCENTRYX INCORPORATED; ZHANG, PENGLIE; ZENG, YIBIN; (41 pag.)JP5654467; (2015); B2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics