Application of 4090-55-5, These common heterocyclic compound, 4090-55-5, name is 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The NCS was synthesized according to the literature (Kang and Li 2004). In a 250mL three-necked round-bottomed ask equipped with a magnetic stirrer and a reux condenser, PCL 18.40g (0.10mol) and acetonitrile (100mL) were mixed at 65C. Then, potassium thiocyanate 24.20g (0.25mol) was feed into the ask by batch addition, and the mixture was stirred at 65C for 8h. After the reaction, mixture was cooled slowly to room temperature, ltered, and evaporated under vacuum. A red mixture was obtained and washed with dichloromethane (30mL) to remove residual sylvite, ltered, and evaporated under vacuum. Repeat the post-processing process twice, an orange-red oily liquid was collected, and which was named as NCS, and the yield was 95%.
Statistics shows that 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide is playing an increasingly important role. we look forward to future research findings about 4090-55-5.
Reference:
Article; You, Ge-Yun; He, Hong-Wu; Feng, Bin; Tang, Yu-Ying; Cheng, Zhi-Quan; Fan, Fang-Fang; Chemical Papers; vol. 74; 8; (2020); p. 2403 – 2414;,
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