Electric Literature of 87851-77-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 87851-77-2 as follows.
EXAMPLE 4 Preparation of (E)-2-[1-(3-chloro-2-propenyloxyimino)propyl]-5-(1,3-dimethyl-1H-pyrazol-5-yl)cyclohexane-1,3-dione (Compound No. 4) STR19 To 10 ml of a solution of 5.60 g (21.3 mmols) of 5-(1,3-dimethyl-1H-pyrazol-5-yl)-2-propionylcyclohexane-1,3-dione in methanol was added 57 ml (21.7 mmols) of 0.38 mol ethanolic solution of (E)-3-chloro-2-propenyloxyamine. The mixture was reacted for 10 hours with stirring. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to give 6.84 g of the product. Physical properties: Melting point, 83¡ã-85¡ã C., Yield, 91.1percent. 1 H NMR (CDCl3, TMS), ppm. delta1.13 (3H, t, J=7 Hz) 2.16 (3H, s) 2.5-3.2 (6H, m) 3.2-3.7 (1H, m) 3.73 (3H, s) 4.51 (2H, d, J=6 Hz) 5.1 (1H, s) 5.9-6.5 (2H, m).
According to the analysis of related databases, 87851-77-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nihon Nohyaku Co., Ltd.; US4863504; (1989); A;,
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