Synthetic Route of 26487-67-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26487-67-2 as follows.
Step 1.- 1-(2-(azepan-1-yl)ethyl)- -chloro-1 H-pyrazolo[3,4-d]pyrimidine. 1-(2-(azepan-1-yl)ethyl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine (100 mg, 0.65 mmol) anh. DMF (2 mL) was added to a suspension of NaH (91 mg, 60percent dispersion mineral oil) in anh. DMF (3 mL) at 0 5C. The mixture was stirred at room temperature for 45 min. Then, 1 -(2-chloroethyl)azepane hydrochloride (192 mg, 0.97 mmol) in portions at -15 5C and was kept at this temperature for 3 h. The solvent was evaporated to dryness and the residue was diluted in ethyl ether, filtered and the solvent was removed under reduced pressure. The crude was purified by flash chromatography to give 1 -(2-(azepan-1 -yl)ethyl)-4-chloro-1 H-pyrazolo[3,4-d]pyrimidine (40 mg, 0.14 mmol, 22percent) as an oil.
According to the analysis of related databases, 26487-67-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; CUBERES-ALTISENT, Maria, Rosa; CORBERA-ARJONA, Jordi; DIAZ-FERNANDEZ, Jose, Luis; ALMANSA-ROSALES, Carmen; WO2013/10950; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics