In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-(Chloromethyl)benzo[d][1,3]dioxole
General procedure: To a mixture of 7 (0.30g, 1mmol) in DMF (6mL) was added potassium carbonate (0.83g, 6.0mmol), potassium iodide (0.01g, 0.06mmol), and (chloromethyl)cyclopropane (9a, 0.28mL, 3.0mmol) at room temperature. The mixture was stirred for 48h, poured into brine, then extracted with CH2Cl2. The organic layer was separated, dried over MgSO4, and concentrated. The crude residue was purified by silica gel column chromatography to give 10a (100mg, 28%) as a yellow oil.
The synthetic route of 20850-43-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liao, Yung-Feng; Tang, Yu-Cheng; Chang, Ming-Yun; Wang, Bo-Jeng; Hu, Ming-Kuan; European Journal of Medicinal Chemistry; vol. 79; (2014); p. 143 – 151;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics