In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1303587-99-6, name is 2-Chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: chlorides-buliding-blocks
Synthesis of2-chloro-8-(l-phenylethyl)-7, 8-dihydro-6H-pyrimido [5, 4-b] [I, 4] oxazine [0454] To a stirred solution of 2-chloro-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (100 mg, 0.58 mmol) in DMF (2 mL) under argon atmosphere was added sodium hydride (27 mg, 1.16 mmol) at 0 C. After stirring for 10 mins, (1-bromoethyl) benzene (130 mg, 0.70 mmol) was added to the reaction mixture at 0 C and stirred for 1 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford 2-chloro-8-(l-phenylethyl)-7, 8-dihydro- 6H-pyrimido [5, 4-b] [1, 4] oxazine (140 mg, 87%) as an off-white solid. 1H-NMR (CD3OD, 400 MHz): delta 7.60 (s, 1H), 7.39-7.23 (m, 5H), 6.20-6.11 (m, 1H), 4.18-4.10 (m, 1H), 3.98- 3.91 (m, 1H), 3.50-3.41 (m, 1H), 3.10-3.02 (m, 1H), 1.60 (s, 3H); LCMS: 275.8 (M+l); (column; X-Select CSH C-18 (50 3.0 mm, 3.5 mupiiota); RT 3.70 min 0.05% Aq TFA: ACN; 0.80 mL/min); TLC: 60% EtOAc/hexane (R 0.5).
The synthetic route of 1303587-99-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics