Electric Literature of 74483-46-8, These common heterocyclic compound, 74483-46-8, name is 2-Chloro-4-methyl-1-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: 3-Chloro-4-trifluoromethylbenzylbromide 27 A mixture of 2-chloro-4-methyl-1-trifluoromethylbenzene 26 (0.20 g, 1 mmol), N-bromosuccinimide (0.17 g, 1 mmol) and benzoyl peroxide (7.4 mg, 0.03 mmol) in carbon tetrachloride (2 mL) was heated to reflux for 2 hours. Another portion of benzoyl peroxide (20 mg, 0.08 mmol) was added. The mixture was heated to reflux for another 0.5 hours. The reaction mixture was further stirred at room temperature for 16 hours. The solid was removed by filtration. The solvent was removed under reduced pressure. The crude product was purified by flash chromatography on silica, using petroleum ether as eluent, to give 0.22 g (80%) of Compound 27.
Statistics shows that 2-Chloro-4-methyl-1-(trifluoromethyl)benzene is playing an increasingly important role. we look forward to future research findings about 74483-46-8.
Reference:
Patent; CanBas Co., Ltd.; US2008/275057; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics