Application of 3972-56-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, This compound has unique chemical properties. The synthetic route is as follows.
To a 30 ml of two necked flask, 26.3 mg of PdCl2(PCy3)2, 667.8 mgof Cs2CO3 were introduced. To the mixture, 5ml of DMF, 168.7 mg of 4-tert-butyl-1-chlorobenzene, 368.6 mg of 2,5-norbornadiene and 170 mg of diethylenegycohol (internal standard) were added. The mixture was stirred for 6 hours at 120 ¡ãC. The mixture was cooled to ambient temperature and poured into 30 ml of water. The combined mixture was extracted with ether (50 ml, 3 times). The organic layer was washed with water and brine. The washed organic layer was dried over MgSO4, filtered and condensed in vacuo. The residue analyzed via GC quantitatively, using internal standard. Also the residue was chromatographed on SiO2 withhexane – ethyl acetate to give 6-tert-butyl-1,4,4a,8b-tetrahydro-1,4-methanobiphenylene (2) in 62percent yield. The purified compound was determined its chemical structure with NMR analysis.
The chemical industry reduces the impact on the environment during synthesis 1-tert-Butyl-4-chlorobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Article; Aida, Fuyuki; Sone, Hisashi; Ogawa, Ryuhei; Hamaoka, Takeharu; Shimizu, Isao; Chemistry Letters; vol. 44; 5; (2015); p. 715 – 717;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics