Application of 886762-39-6, These common heterocyclic compound, 886762-39-6, name is 3,4-Dichloro-2-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of [4-chloro-7-(2,2-dimethylpropanoyloxy)quinazolin-6-yl] 2,2-dimethylpropanoate (6.6 g, 18.1 mmol) in DCE (60 mL) was added HCI, 4 M in dioxane (9 mL) followed by 3,4-dichloro-2-fluoroaniline (3.1 g, 17.2 mmol) and the resulting mixture was stirred at 70 C for 1 .5 h. The mixture was then cooled to room temperature and diluted with diethyl ether. The resulting suspension was filtered to collect the desired product (8.5 g, 92%).
The synthetic route of 886762-39-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TRILLIUM THERAPEUTICS INC.; SLASSI, Abdelmalik; DOVE, Peter; (124 pag.)WO2016/123706; (2016); A1;,
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