627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Methoxyethyl chloride
K2CO3 (24.8 g, 180 mmol), KI (0.75 g, 4.5 mmol) and 1-chloro-2-methoxyethane (17.0 g, 180 mmol) were added successively to a solution of the compound 9 (20 g, 90.0 mmol) in DMF (120 mL) and the mixture was stirred at 70 C for 5 h. The mixture was poured to water (500 mL) and the aqueous phase was extracted with AcOEt (3 * 400 mL). The organic solution was washed with water follow by saturated aqueous NaCl solution, dried over anhydrous Na2SO4, and evaporated to afford the compound 10 (24.0 g, yield, 95%), which was used to the next reaction without further purification. Mp: 187-189 C; 1H NMR (500 MHz, CDCl3) delta: 7.52 (1H, s), 6.51 (1H, s), 5.77 (2H, bs), 4.35 (2H, q, J = 7.1 Hz), 3.94 (2H, t, J = 5.4 Hz), 3.69 (2H, t, J = 5.4 Hz), 3.36 (3H, s), 1.40 (3H, t, J = 7.1 Hz); IR (film, cm-1): 3468, 3358, 2987, 2891, 1780, 1691, 1584, 1489, 1432, 1370, 1328, 1280, 1226, 1111, 1064, 954, 832, 789, 746, 660.
The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yin, Siyuan; Zhou, Liliang; Lin, Jinsheng; Xue, Lingjing; Zhang, Can; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 462 – 475;,
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