Adding a certain compound to certain chemical reactions, such as: 104-52-9, name is 3-Phenylpropyl Chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104-52-9, name: 3-Phenylpropyl Chloride
15.5 g (0.10 mol) of 3-phenylchloropropane, 4.1 g (0.05 mol) of ethylamine hydrochloride, 0.2 g of tetrabutylammonium bromide and 50 ml of a sodium hydroxide solution (35% to 40%) were placed in a 250 ml flask.Stirring heated to 85-90 C, insulation reaction, TLC tracking.After completion of the reaction, the aqueous layer was extracted three times with ethyl acetate, and the organic layers were combined.Add anhydrous sodium sulfate drying.The filtrate was concentrated under reduced pressure to give 12.4 g of a brownish yellow liquid.Yield: 88%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenylpropyl Chloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Hebei Kaisheng Pharmaceutical Technology co., LTD; ZHAO, KAI; HOU, JIANPING; ZHAO, YAFENG; YUAN, HONGZHONG; ZHAO, XIAOXIAN; JIAN, YONGXUE; (5 pag.)CN103508898; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics