Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-42-9, name is 2-Methoxyethyl chloride, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks
Step (i) N-methoxyethyl-N-methylpyrrolidinium chloride, PYR1(2O1)Cl, was synthesized by reacting N-methylpyrrolidine with the appropriate amount of 2-chloroethyl methyl ether. The reagents were firstly dissolved in ethyl acetate and, then, mixed in a reactor. The reaction temperature was set at 70 C forachieving a yield approaching 100% (determined by weighting the obtained precursor after vacuum drying at 100 C overnight) upon 5-6 days heating due to the low kinetics of the reaction (1) [15,17].A white, solid precipitate of PYR1(2O1)Cl was obtained whereas the yellowish liquid phase (e.g., containing impurities generally very soluble in ethyl acetate) was removed by vacuum filtering (paper filter membrane). Finally, the precursor was rinsed 5 times with ethyl acetate.
The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Moreno; Montanino; Carewska; Appetecchi; Jeremias; Passerini; Electrochimica Acta; vol. 99; (2013); p. 108 – 116;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics