Related Products of 75717-77-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 75717-77-0 name is 2,4-Dichlorophenylacetylene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Weighed 2,4-dichlorobenzyl alkyne compound (81.6mg, 0.5mmol) into the round bottom flask; re-weighed compound 3,4-methylenedioxy-benzyl azide (120mg, 0.68mmol, 1.4eq) into round-bottomed flask; dimethyl sulfoxide (0.2mL); amount of tert-butanol solution (4mL) and H2O (2mL) dropped to the mixture; after five co-catalyst weighed water copper sulfate (390mg); and then said take ascorbic acid sodium salt (290mg). The clarification becomes cloudy, yellow. Was stirred for 5 hours at room temperature, after treatment experiment, ice-water was added with stirring (15mL), the reaction was quenched; (30mL ¡Á 3) and extracted with ethyl acetate; the organic phase was washed with H2O (25mL ¡Á 2), saturated chloride sodium solution (30mL ¡Á 2) and washed; with an appropriate amount, and the organic phase was dried over anhydrous sodium sulfate; filtered andAnd concentrated to a solid, brown, purified by column chromatography [the V (dichloromethane) :V (petroleum ether) = 1: 1] to give a white solid 125.0 mg,Yield 75%
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dichlorophenylacetylene, and friends who are interested can also refer to it.
Reference:
Patent; Changzhou University; Chen, Xi; Liang, Cuirong; Yang, Qinghong; Ren, Jie; Jin, Guihua; Huang, Qianhui; Xu, Yuanyuan; Hu, Kun; (32 pag.)CN105440020; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics