97329-43-6, name is 1-Bromo-2-chloro-3-methylbenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 97329-43-6
A mixture of l-bromo-2-chloro-3-methyl-benzene (3.0 g, 14.6 mmol), phenylmethanethiol (2.1 g, 17.5 mmol, 2.0 mL), (lE,4E)-l,5-diphenylpenta-l,4-dien-3- one;palladium (2.6 g, 2.9 mmol), DIEA (5.6 g, 43.8 mmol, 7.6 mL), and (5-diphenylphosphanyl- 9,9-dimethyl-xanthen-4-yl)-diphenyl-phosphane (1.6 g, 2.9 mmol) in dioxane (60.0 mL) was degassed and purged with 2 for 3 times, and then the mixture was stirred at 100C for 12 h under N2 atmosphere. The reaction mixture was concentrated under reduced pressure. The residue was purified by column chromatography (S1O2) to afford benzyl(2-chloro-3- methylphenyl)sulfane (2.6 g, 53.6% yield) as a yellow solid. 1HNMR (400MHz, CHLOROFORM-^ delta 7.44 – 7.37 (m, 2H), 7.36 – 7.23 (m, 3H), 7.16 – 7.03 (m, 3H), 4.42 – 3.93 (m, 2H), 2.73 – 2.22 (m, 3H).
The synthetic route of 97329-43-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; QUENTIS THERAPEUTICS, INC.; VACCA, Joseph P.; LI, Dansu; BETTIGOLE, Sarah; (214 pag.)WO2019/94641; (2019); A1;,
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