Adding a certain compound to certain chemical reactions, such as: 1020198-58-6, name is 2-Bromo-1-chloro-3,5-difluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1020198-58-6, Formula: C6H2BrClF2
A mixture of 2-bromo-1-chloro-3,5-difluorobenzene (800 mg), bis(pinacolato)diborone (1.1 g), bis(triphenylphosphine)palladium chloride (123 mg), triphenylphosphine (92 mg), potassium acetate (1.0 g), and 1,4-dioxane (24 mL) was heated under stirring in an oil bath at 100 C. for 18 hours. The reaction mixture was returned to room temperature, the insoluble materials were separated by filtration, and the filtrate was concentrated under reduced pressure. The resulting residue was purified under silica gel column chromatography (hexane/ethyl acetate) to obtain 2-(2-chloro-4,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (242 mg).
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Reference:
Patent; Kinoyama, Isao; Miyazaki, Takehiro; Koganemaru, Yohei; Washio, Takuya; Hamaguchi, Wataru; US2012/142727; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics