Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627531-47-9, name is 4-Bromo-3-chloro-2-methylaniline, A new synthetic method of this compound is introduced below., SDS of cas: 627531-47-9
Into the compound 4-bromo-3-chloro-2-methylaniline 8.54g (39mmol) obtained in step 1 in 1L flask, it was stirred into 250ml of trifluoroacetic acid.Sikimyeo stirred at room temperature NaBH4out over the 9g (9 pellets) for 4 hours and stirred at room temperature for 16 hours.Refluxing the reaction solution at 100 and NaBH4were added to 4g (4 pellets).After completion of the reaction mixture was concentrated under reduced pressure, water (300ml) and ethyl acetate to remove the water layer after delamination to (300ml) and washed with 2N NaOH (300ml).The organic layer was washed with water and saturated NaCl solution and then MgSO4and concentrated under reduced pressure and dried by dehydration.Column to separate the concentrate to give the title compound 6g (40%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; DONG-A ST CO., LTD.; CHOI, SUNG PIL; CHOI, SEUL MIN; SON, BYOUNG HWA; KIM, HYUN JUNG; KIM, JU MI; JANG, BYUNG JUN; SUNG, JI HYUN; LEE, JI HYE; KIM, EUN JIN; KANG, KYUNG KOO; KIM, SOON HOE; (28 pag.)KR2015/123007; (2015); A;,
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