Electric Literature of 1716-42-3, A common heterocyclic compound, 1716-42-3, name is 1-(3-Chloropropoxy)-4-fluorobenzene, molecular formula is C9H10ClFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example B13; A mixture of l-(3-chloropropoxy)-4-fluoro- benzene (0.025 mol), compound 23 (0.02 mol) and sodium carbonate (0.06 mol) in DMF (150ml) was stirred at 60¡ãC for 12h. The mixture was cooled, poured into ice water, acidified with HC1 and neutralized with NH3. The precipitate was filtered off and crystallized from MeOH. The precipitate was filtered off and dried at 60¡ãC. The residue (2.1g) was converted into the hydrochloric acid salt (1:1) in 2-propanol. The precipitate was filtered off and washed with 2-propanol and DIPE. The residue was dried at room temperature, yielding 1.2g (14.4percent) of compound 13, melting point 227.6¡ãC.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/3147; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics