In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14862-52-3 as follows. Recommanded Product: 3,5-Dibromochlorobenzene
To a stirred solution of 1,3-dibromo-5-chlorobenzene (600 mg, 2.20 mmol) and 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (455 mg, 2.20 mmol) in 1,4-dioaxane (15 mL) K2CO3 (920 mg, 6.60 mmol) was added and the mixture was degassed with argon for 20 minutes. Pd(PPh3)4 (76 mg, 0.06 mmol) was added to reaction mixture and degassed for another 20 minutes. The reaction mixture was refluxed under stirring for 8 hours and then filtered through celite pad. The filtrate was concentrated and the residue was purified by column chromatography on silica (100-200 mesh) eluting with 15% ethyl acetate in petroleum ether to afford the title compound as white solid (300 mg, 50 %).
According to the analysis of related databases, 14862-52-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Cortendo AB; Blass, B. E.; Abou-Gharbia, M. A.; Childers, W. E.; Iyer, P.; Boruwa, J.; (143 pag.)CN105722823; (2016); A;,
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