Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., category: chlorides-buliding-blocks
Compound b (8.5 mg, 18.9 mumol) was dissolved in DMF (0.4 mL), 55percent sodium hydride (8.3 mg, 0.189 mmol) was added, and the mixture was stirred at 50 ¡ã C. for 15 min. N- (2-chloroethyl) hexahydro-1 H-azepine hydrochloride (18.7 mg, 94.5 mumol) was added thereto and the mixture was stirred at 50 ¡ã C. for 12 hours. After cooling, reactionTo the mixture was added a saturated aqueous ammonium chloride solution to stop the reaction, and the mixture was extracted with methylene chloride. The organic layers were combined, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by thin layer chromatography (chloroform / methanol / ammonia = 90/3/2) to obtain compound c(10.2 mg, 75percent).
According to the analysis of related databases, 26487-67-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KANSAI BUNRI SOGOGAKUEN; TOKYO UNIVERSITY OF SCIENCE; HASEGAWA, MAKOTO; MIZUKAMI, TAMIO; TANAKA, MAKOTO; ISAMU, SHIINA; (82 pag.)JP2016/222659; (2016); A;,
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