Application of 174913-12-3, A common heterocyclic compound, 174913-12-3, name is 1-Bromo-3-chloro-5-methoxybenzene, molecular formula is C7H6BrClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Bromo-3-chloro-5-methoxybenzene (10 mmol, 2.2 g)Diphenylamine (20 mmol, 3.34 g) was added to a 100 mL three-necked flask,A cuprous iodide (2 mmol, 0.4 g) was added under nitrogen,Potassium carbonate (20 mmol, 1.4 g),O-phenanthroline (2 mmol, 0.4 g),50 mL of DMF,Reaction was carried out at 155 C for 3 days;The resulting reaction product is subjected to extraction,The extracted organic phase was evaporated to dryness with ethanol,Then recrystallized from ethyl acetate and petroleum ether,To obtain 1.83 g of intermediate A-1,
The synthetic route of 174913-12-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jilin Aolai De Optoelectronic Materials Co., Ltd.; Gao, Chunji; Cui, Dunzhu; Sun, Yi; Zhang, Chengcheng; (52 pag.)CN104892434; (2017); B;,
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