Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Bromo-4-chloro-2-fluorobenzene
To a stirred and cooled (-78 C) solution of 1-bromo-4-chloro-2-fluorobenzene (1.0 mL, 8.012 mmol) in diethyl ether (10 mL) was added n-BuLi (1.6 M in ether, 5 mL) and stirred for 30 mm. A solution of 1,3-dichloroacetone (1.01 g, 8.012 mmol) in diethyl ether (10 mL) was added to the reaction mixture at -78 C and stirred at -78C to 0 C for lh. To that mixture was added a solution of ferric chloride (26 mg,0.163 mmol) in diethyl ether (5 mL) followed by ethyl magnesium bromide (13.3 mL,40.059 mmol) at 0 C and gradually warmed to RT. The reaction mixture was stirredat RT for 18 h. The reaction mixture was quenched with saturated ammoniumchloride solution (50 mL). The aqueous mixture was extracted with ethyl acetate (2 x100 mL). The combined organic layers were washed with water (100 mL) and driedover anhydrous sodium sulfate. The solution was filtered, concentrated under reduced pressure and the residue thus obtained was purified by silica gel column chromatography to yield 425 mg of the product as a semi-solid. ?H NMR (300 MHz, DMSO-d6) oe 0.96 (d, J = 10.2 Hz, 4H), 6.02 (s, 1H), 7.24 (d, J = 8.7 Hz, 1H), 7.33 (dJ = 9.3 Hz, 1H), 7.51 (t, J = 8.7 Hz, 1H).
According to the analysis of related databases, 1996-29-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin Sundarlal; THOMAS, Abraham; KADAM, Ashok Bhausaheb; DHONE, Sachin Vasantrao; ADIK, Bharat Gangadhar; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy Manish; BAJPAI, Malini; WO2015/159233; (2015); A1;,
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