Adding a certain compound to certain chemical reactions, such as: 38762-41-3, name is 4-Bromo-2-chloroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 38762-41-3, HPLC of Formula: C6H5BrClN
To a stirred solution of 4-bromo-2-chloroaniline (1.8 g, 8.82 mmol) in dry THF (20 mL) was added NaHMDS (11.5 mL 69.68 mmol) followed by Etl (0.9 ml, 2.95 mmol) at RT. The reaction mixture was stirred at RT for lh. The reaction mixture was quenched with aqueous NH4Cl solution and extracted with EtOAc (2X50 mL), dried over Na2S04 and concentrated under reduced pressure to afford the title compound (1.5 g,75%), LCMS: m/z = 264.0[M+2]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-chloroaniline, and friends who are interested can also refer to it.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; CHIKKANNA, Dinesh; KHAIRNAR, Vinayak V.; RAMACHANDRA, Muralidhara; SATYAM, Leena Khare; (139 pag.)WO2019/142126; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics