Adding a certain compound to certain chemical reactions, such as: 309721-44-6, name is 2-Bromo-1-chloro-3-fluorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 309721-44-6, Quality Control of 2-Bromo-1-chloro-3-fluorobenzene
To a solution of 2-bromo-l-chloro-3-fluorobenzene (6.0 g, 29 mmol) in tetrahydrofuran (30 mL) at -70 C was added dropwise lithium diisopropylamide (2 M in tetrahydrofuran/n-heptane, 22 mL, 43 mmol). The resulting solution was stirred at -70 C for 0.5 hour. Then N, N – dimethylformamide (4.2 g, 57 mmol) was added slowly, and stirring was continued at -70 C for another 0.5 hour. On completion of the reaction by TLC [petroleum ether: ethyl acetate = 10: 1, Rf=0.6], the reaction was quenched with saturated aqueous ammonium chloride (2 mL) at 0 C and extracted with acetate ethyl (3 chi 20 mL). The combined organic extracts were concentrated to give compound A-49 (4.0 g, 58% yield) as a yellow solid. -NMR (CD3OD, 400 MHz): delta 7.64-7.57 (m, 1H), 7.21-7.17 (m, 1H), 6.02 (s, 1H).
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Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; MCRINER, Andrew, J.; (127 pag.)WO2016/201096; (2016); A1;,
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