Reference of 78068-85-6, These common heterocyclic compound, 78068-85-6, name is 3-Chloro-4-fluorobenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 6-hydroxyindan-1-one (1.48 g, 10 mmol) in 30 ml of DMF was added 3-chloro-4-fluorobenzotrifluoride (2.46 g, 12 mmol) and cesium carbonate (8.40 g, 25 mmol). The reaction mixture was heated at 80 C. for 12 h. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate, washed with water (2*) and brine, dried over sodium sulfate, filtered and concentrated. The crude product was purified by silica gel chromatography, eluding with ethyl acetate (2-40%) in hexane. The final productproduct was collected as brownish yellow oil.
The synthetic route of 78068-85-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ge, Min; He, Jiafang; Lau, Fiona Wai Yu; Liang, Gui-Bai; Lin, Songnian; Liu, Weiguo; Walsh, Shawn P.; Yang, Lihu; US2007/265332; (2007); A1;,
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